Celiac Disease

Celiac Disease Overview:

Celiac disease occurs after an abnormal immune response to a protein found in wheat products. The reaction can severely damage the cilia of the intestinal tract, causing the, to flatten and become inefficient at absorbing nutrients. 

 

Aetiology:

Celiac is an autoimmune disease triggered by a protein found in wheat known as gluten. Specifically, the reaction is due to the gliadin portion of the gluten protein. 

A significant immune reaction of the small intestine result in a flattening and gradual destruction of the microvilli. This eventually leads to malabsorption, and eventual nutrient deficiency conditions. 

Causes are mainly genetic. 

 

Symptoms:

Diarrhea

Failure to thrive

Weight loss

Irritability

Bone abnormalities

Steatorrhea

Anemia

Fatigue

 

Diagnostic Considerations

  • Blood Tests:
    • IgA and IgG, anti-endomysium antibodies, HLA-DQ2, HLA-DQ8
    • Fe, B12, Folate, tHcy
  • Biopsy of small intestine

Celiac vs Non-Celiac Gluten Insensitivity

Test Celiac Non-Celiac Gluten Insensitivity
IgA ADA 81.4% Predominance 56.4% Predominance
IgA tTGA 98.7% Predominance None
IgA EmA 95% Predominance None
IgG ADA 75% Predominance 1% Predominance

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Therapeutic Aims:

1. Eliminate all sources of gluten from the diet.

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Differential Diagnosis:

  • Non-Celiac Gluten Intolerance
 

Medical Treatment

  • Gluten free diet
  • Antiobiotics
  • Corticosteroids
 

Herbs For Celiac Disease:

Herbs

  • Centella asiatica
  • hydrastis
  • Turmeric
  • Slippery elm
  • Calendula

Nutritional Medicine

  • Glutamine
  • Zn
  • A
  • C
  • E
  • Omega 3
  • Quercetin
  • Consider nutrient deficiencies

Diet

  • Gluten avoidance
  • Lower caffeine
  • Protein
  • High antioxidant intake

Author:

Justin Cooke

The Sunlight Experiment


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References:

  1. Volta, U., Tovoli, F., Cicola, R., Parisi, C., Fabbri, A., Piscaglia, M., ... & Caio, G. (2012). Serological tests in gluten sensitivity (nonceliac gluten intolerance). Journal of clinical gastroenterology, 46(8), 680-685.
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