Multiple Sclerosis

Multiple Sclerosis Overview:

Multiple sclerosis (MS) is characterised by autoimmune related patches of demyelination in the brain and spinal cord.

 

Aetiology:

Multiple sclerosis involves gradual, or remissive degeneration of the myelin sheath within the brain and spinal cord. Though there is no specific cause, it's been correlated with previous viral infection (such as EBV), chronic inflammation, and low levels of sunlight (vitamin D). It's also more common in women than men, and appears to have some genetic influence (roughly 15% have family members with the condition).

+ Primary Progressive Multiple Sclerosis (PPMS)

  • A constant, steady attack and decrease in disability.
  • Their may be plateaus where symptoms do not appear to be getting worse.
  • There does not appear to be any clear triggers or exacerbations.

+ Secondary Progressive Multiple Sclerosis (SPMS)

  • Starts out similarily to relapsing and remitting MS but eventually the immune attack becomes constant, resulting in constant increase in disability.

+ Relapsing and Remitting Multiple Sclerosis (RRMS)

  • Most common type of MS
  • Bouts of demyelenation and remission, allowing for some remyelenation and reduction in symptoms to ocurr.
  • Remissions may last weeks, months, or years.
  • Relapse may appear spontaniously or after viral or bacterial infection.
  • This type of MS causes gradual degredation of neuronal tissue with bouts of increased attacks that can be months or years apart.

+ Progressive Relapsing Multiple Sclerosis (PRMS)

  • Steady degeneration and increase in disability along with bouts of increased attacks similar in nature to RRMS.
Screenshot 2017-12-03 09.53.20.png
Screenshot 2017-12-03 10.04.02.png
 

Symptoms:

Charcots Neurolagic Triad

  • Dysarthria
  • Nystagmus
  • Tremors

Constipation

Sexual Dysfunction

Visual abnormalities

Oculomotor Abnormalities

Parasthesias

Weakness

Spasticity

urinary Dysfunction

Cognitive Impairment

 

Diagnostic Considerations:

  • Genetic factors
    • Genes encoding for HLA-DR2
      • Identifies and binds to foreign molecules. 
  • Vitamin D deficiency
  • CSF lymphocytes and antibodies
  • Scans:
    • MRI to look for initial lesion
 

Therapeutic Aims:

1. Identify & Eliminate Primary Lesion & Manage Sustaining Factors

(If Possible)

  • Eliminate Microbial Infections
  • Remove Exposure To Allergens

2. Reduce Inflammation

  • Antinflammatories (TNF-a & NF-kB)(Curcuma longa, Boswellia serrata)
  • Antinflammatories (eicosanoid synthesis modulators)(Curcuma longa, Boswellia serrata)
  • Antinflammatories (glucocorticoids)(Rehmannia glutinosa, Glycyrrhiza glabra)
  • Antioxidants(Vitis vinefera, Pinus pinasta, Camellia sinensis, Rosmarinus officinalis)

3. Modulate immune Response

  • Immunosupressants(Hemidesmus indicus, Rehmannia glutinosa)
  • Immunmodulators(Ganoderma lucidum, Lentinula edodes, astragalus membranaceus)

4. protect Against neural Degeneration

  • Neuroprotectives(Ginkgo biloba, Panax ginseng, Panax quinquefolius, Rosmarinus officinalis)
  • Nervine Trophorestoratives(Avena sativa)
  • Nutritional Support(Vitamin E, Vitamin B (Complex), Vitamin D, a-lipoic acid, Fish oil, Selenium)

5. Support Stress Response & Reduce Fatigue

  • Adaptogens(Panax quinquefolius, Panax ginseng, Withania somnifera, Astragalus membranaceus)

6. Support Mood

  • Thymoleptics(Melissa officinalis, Turnera diffusa)
  • Nervine Trophorestoratives(Avena sativa)
  • Nervine Relaxants(Scutellaria lateriflora, Passiflora incarnata, Valeriana officinalis)
 

Differential Diagnosis:

  • MRI
  • Antibodies in the cerebrospinal fluid
  • Visual evoked potential
 

Conventional Treatments

Screenshot 2017-12-03 10.02.07.png
 

Cautions:

Insert.

 

Herbs For Multiple Sclerosis:

  • Withania
  • Passiflora
  • Astragalus
  • Andrographis
  • Echinacea
  • St Johns wort
  • Taraxacum
  • Silybum, Bupleurum
 

Nutritional Considerations

  • Vitamin D
  • CoQ10
  • Polyunsaturated fatty acids
  • Omegas 3
  • Antioxidants
  • Selenium
  • B complex
  • Iron
  • Flavonoids
  • Vitamins A, C, & E

Author:

Justin Cooke

The Sunlight Experiment

Updated: June 2018


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