Peripheral Neuropathy

Peripheral Neuropathy Overview:

Peripheral neuropathy is a syndrome involving one or more of the peripheral nerves. it involves variable degrees of sensory impairment, pain, muscular weakness, atrophy, vasomotor symptoms, reduces reflexes in the tendons, or a combination of any of these symptoms.



+ Alcoholism

  • Vitamin deficiencies

+ Autoimmune Conditions

  • Sjogren's syndrome
  • Lupus
  • Rheumatoid arthritis
  • Guillain-Barre Syndrome
  • Chronic inflammatory demyelenating polyneuropathy
  • Necrotizing vasculitis

+ Diabetes

  • More than half of people with diabetes will develop neuropathy at some point

+ Heavy Metal or other Toxic Exposure

  • A number of substances can result in neuropathy

+ Infection

  • Lyme Disease
  • Shingles
  • HIV
  • Epstein-Barre
  • Herpes virus
  • Hepatitis C
  • Leprosy
  • Diptheria
  • HIV

+ Traumatic Injury

  • Common in sporting or motor vehicle accidents

+ Vitamin Deficiencies

  • B vitamin deficiency (especially B1, B6, and B12)


Stabbing, Burning, Or Tingling Pain


Lack of coordination

Extreme Sensitivity To Touch

Musle Weakness or Paralysis

Altered Sweating

Bladder Dysfunction

Bowel Dysfunction

Changes In Blood Pressure



Diagnostic Considerations:

  • Electrodiagnostic testing to assess electrical activity in the nerves. 

Blood Tests

  • Vitamin B12 and folate levels
  • Thyroid Function Testing
  • Liver function testing
  • Kidney function testing
  • Blood glucose testing
  • Antibodies to nerve components
  • Antibodies related to celiac disease
  • Lyme disease
  • Hepatitis B and C

Therapeutic Aims:

1. Address The Suspected Cause

  • Antimicrobials (Tabebuia impetiginosa)
  • Antinflammatories (Boswellia serrata, Curcuma longa, Salix alba, Filipendula ulmaria)
  • Antioxidants (Vitis vinifera, Rosmarinus officinalis)
  • Peripheral Circulatory Stimulants (Ginkgo biloba, Vitis vinifera, Pinus pinasta)
  • Nutritional (Vitamin B12, Folate, Fish oil, Phosphatidylserine, Phosphatidylcholine)

2. Encourage Nerve Repair

  • Nutritional (Essential fatty acids, Phosphatidylserine, Phosphatidylcholine, B Vitamins, Zinc)
  • Nervine Trophorestoratives (Avena sativa, Ginkgo biloba, Hypericum perforatum)

3. Manage Pain

  • Analgesics (Eschscholtzia californica, Piscidia erythrina, Corydalis ambigua)
  • Rubefacients (Capsaicin topical salves)

Differential Diagnosis:

  • Diabetes mellitus

Comorbidities/Risk Factors:

  • Burns and skin trauma
  • Infection
  • Falls/bone fractures
  • Diabetes mellitus


Always rule out the possibility of undiagnosed diabetes mellitus.


Herbs For Peripheral Neuropathy:

  • Muira puama
  • piper methysticum
  • Cannabis sativa
  • Centella asiatica


Justin Cooke

The Sunlight Experiment

Updated: November 2017

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