Uterine Cancer

Uterine cancer Overview:

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Aetiology:

Endometrial adenocarcinoma accounts for >95% of all uterine cancer and is usually postmenopausal, arising from malignant changes in endometrial polyps.


Risk Factors:

  • Greater Lifetime Exposure to oestrogen
  • Early menarche and late menopause
  • Obesity, Unopposed oestrogen therapy
  • Infertility or nulliparity
  • Pregnancy and COCP reduces the risk
  • Anovulatory cycles: age >45, weight >90 kg
  • Polycystic ovary syndrome
  • Diabetes mellitus
  • Family history of colonic or endometrial cancer

Symptoms:

Abnormal uterine bleeding

Vaginal discharge (white & Watery)

Lower Abdominal Pain

Symptom

Symptom

Symptom

Symptom


Diagnostic Considerations:

  • Transvaginal ultrasound
  • Endometrial biopsy or hysteroscopy
 

Differential Diagnosis:

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Cautions:

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Red Flags In Gynecology:

Symptom Considerations
1 Postmenopausal bleeding or new onset of menorrhagia in 35 or older. Endometrial cancer
2 Unscheduled bleeding on HRT Endometrial cancer
3 Postcoital bleeding Cervical cancer
4 Pelvic discomfort, abdominal distention and dyspepsia Ovarian cancer
5 All female reproductive complaints within childbearing age. Consider pregnancy
6 Abdominal or pelvic pain in a woman of reproductive years Ectopic pregnancy
7 Abdominal pain, with a negative pregnancy test Ovarian cyst rupture
8 Being wet all the time Urogenital fistula
9 Vulval ulceration or bleeding Neoplasm
10 Enlarging fibroids Cancer
11 Secondary amenorrhea Hyperthyroidism
12 Intermenstrual bleeding Infection or cancer
13 Pelvic pain on later days of menses Endometriosis
14 Any Non cyclic breast lump breast cancer
15 Nipple discharge Breast cancer
 

Author:

Justin Cooke

The Sunlight Experiment

Updated: October 2017


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