Damiana Infographic

Damiana Summary:

Damiana (Turnera diffusa/aphrodisiaca) is a small herb found in Mexico, Central and South America and the West Indies. Its leaves and flowers have been used as medicine for thousands of years and was popular among the Mayans. 

Its uses cover a wide range, however the main uses are for anxiety and sexual weakness. As such, it is most effective in the treatment of sexual weakness that is caused by anxiety or stress. Some take damiana simply to improve their libido, or to relax at the end of a long day or stressful event. 

Damiana has a great scent, and can also be used as an incense, or smoked to promote relaxation. 

Other uses of damiana involve reducing stress, fighting cancer, fungal infections, bacterial infections, and to relieve pain. It has been found to modulate the neurotransmitter GABA in our body, which plays a role in the transmission of pain. As an antibacterial, damiana has been found to block some bacterias ability to reject antibiotics (as is the case with the terrifying superbugs such as MRSA). If used as an adjunct treatment with these medicines, their effectiveness will greatly improve. Drug resistant bacteria are becoming an increasing danger to society, as it is becoming harder and harder to kill them. Modern medicine is running out of effective medicines to combat these deadly bacteria, and development of new antiobiotics are slow and extremely expensive. Herbal therapies such as damiana are becoming increasingly popular in combatting and defeating these infectious organisms. 


Botanical Name

Turnera diffusa
Turnera aphrodisiaca

Family

Turneraceae

Part Used

Aerial parts, leaves, flowers

Herbal Actions:

[8, 10]

  • Aphrodisiac
  • Antimicrobial
  • Antibacterial
  • Antifungal
  • Antineoplastic
  • Anti-aromatase
  • Anxiolytoic
  • Euphoric
  • Nervine tonic
  • Tonic
  • Laxative (mild)
  • Sedative (Mild)
damiana turner diffusa

Dosage

Liquid Extract (1:1)

4-8 mL/day

Powdered herb/capsules

4-8 g/day

Smoked

This herb can be smoked to achieve slightly sedative and euphoric sensations, and may be used in many cases of low-level stress or anxiety in this way. It is suggested to mix this herb with some tobacco and passionflower for this purpose. 

Recommended Source

Indications:

[8, 10]

  • Low libido
  • Sexual dysfunctions
  • Cancer
  • A synergist with antibiotics
  • Trigeminal neuralgia
  • General pain
  • CNS disorders
  • Anxiety
  • Depression
  • Diabetes
  • Fungal infections
  • Bacterial infections
  • Nervous dyspepsia
  • Constipation

Common Names:

  • Damiane
  • Oreganillo
  • The bourrique
  • Mexican damiana
  • Mexican holly
  • Damiana de Guerrero

Traditional Use:

Damiana was used by the Mayans for “giddiness, and loss of balance”, as well as its more well-known use as an aphrodisiac [8].

In Germany, damiana is used to relieve excess mental activity, as well as nervous debility, and as a tonic for the hormonal and central nervous systems [8].

The British Herbal Pharmacopoeia cites indications for Damiana's use for “anxiety Neurosis, with a predominant sexual factor, depression, nervous dyspepsia, atonic constipation, and coital inadequacy” [8].

Traditional uses of this plant from around the world include its use as an antidepressant, cough suppressant, mild laxative, aphrodisiac, tonic, diuretic. It has been used for conditions such as bedwetting, depression, anxiety, sexual dysfunctions, bronchitis, gastric ulcers, menstrual irregularities, constipation, asthma, neurosis, diabetes, dysentery, dyspepsia, headaches, paralysis, nephrosis, spermatorrhea, stomachaches, and syphilis. [8, 10]. 


Botanical Description:

Damiana is a small shrub, growing to a height of about 1-2m.

Its leaves are serrate, aromatic, and roughly 10-25cm long.

There are 2 species used interchangeably in herbal medicine: Turnera diffusa, and Turnera aphrodisiaca. A third species (Turnera ulmifolia), is very similar in appearance but has different traditional uses [8]. This species has been confirmed to share many of the more recent uses such as in combatting drug resistant bacterial strains [4]. More research is needed to determine the chemical composition differences of each species. 


Habitat, Ecology, Distribution:

Damiana can be found in Mexico, Central, and South America, and the West Indies [8].


Harvesting, Collection, Preparation:

The leaves are harvested during the flowering season.

Most of the Damiana on the market today comes from Mexican, and Latin American cultivation projects [8].

There has been some evidence to suggest that the hypoglycaemic effects are not found in the alcoholic extraction of this herb, suggesting that the components responsible for this action are water soluble only [8], however, other studies have eluded to some of the effects only being methanol soluble, therefore, it may be better to utilize both methods, and combining these extracts together and reducing or concentrating this liquid to achieve maximum effectiveness.


Constituents:

Damiana leaves contain volatile oils (up to 1%) which is made up of at least 20 constituents (including 1,8-cineole, p-cymene, alpha and beta-pinene, thymol, alpha-copaene, and calamene) [8].

Also contained are tannins, flavonoids, beta-sitosterol, damianin, and glycosides (gonzalitosin, arbutin, tetraphyllin B) [8].

The main constituents of damiana include: Albuminoids, alpha-copaene, alpha-pinene, arbutin, barterin, beta-pinene, beta-sitosterol, calamenene, caoutchouc, chlorophyll, 1,8-cineole, cymene, cymol, damianin, essential oil, gamma-cadinene, gonzalitosin-i, hexacosanol-1, luteolin, quinovo-pyranosides, tannins, tetraphyllin b, thymol, triacontane, and trimethoxy-flavones [8], as well as  tricosan-2-one, squalene, acacetin, pinocembrin, eremophyllane and simple sugars [2].


Pharmacology and Medical Research:
 

ANALGESIC

Eugenol, present in damiana, has been shown to regulate GABAA receptors [7]. GABAA receptors play a role in the modulation of various activities in the CNS. These results suggest a mechanism of action for damiana's effect on various CNS disorders, especially pain.

 

ANTI-AROMATASE

The flavonoids acacetin, and pinocembrin contained in T. diffusa were shown to be weakly aromatase inhibitors [3]. Aromatase is an enzyme that synthesizes estrogen. Therefore, aromatase inhibition is one method of combating both breast, and ovarian cancer in females.

 

ANTIBACTERIAL    

A study investigating the effects of Turnera ulmifolia (a similar species with a similar chemical makeup to Turnera diffusa and Turnera aphrodisiaca), on MRSA (Multidrug resistant methicillin Staphylococcus aureus) has stated that “The results obtained indicate that Turnera ulmifolia (and broadly Turneraceae) could serve as a source of plant-derived natural products with antibiotic resistance-modifying activity to be used against multi-drug resistant bacteria as MRSA strains acquired from hospital and community” [4]. These findings are significant in a time where bacterial resistance to antibiotics is increasing at an alarming rate. The overuse of antibiotics in hospital settings are likely a major cause of this adaptive resistance. Amino-glycosides are potent antibacterial chemicals that attack the ribosomes of bacteria to destroy them. Bacteria such as MRSA have developed efflux pumps to “pump” the antibiotic out of the cell, as well as the use of enzymes to inactivate this chemical from destroying the cell. Turnera ulmifolia, and likely other members of the Turneracea family as well as other botanicals, work on eliminating this resistance by modifying and inactivating these efflux pumps [4]. By incorporating what is being coined as “resistance modifying agents” (RMA) to antibiotic formulas, the effectiveness of known antibacterial agents will increase in resistant bacteria. Their use will also significantly lower the ability for bacteria to adapt and resist to these medications in the future.

More study is needed in determining the effectiveness of Turneraceae botanicals, as well as other possible RMAs to improve our ability to fight drug-resistant bacteria such as MRSA in a time where this is becoming a very serious global health issue.

 

ANTIFUNGAL

Eugenol, one of the most well-known components of Turnera spp. Has been shown to produce a wide range of antimicrobial effects, including against fungi. It has been shown to be active against many wood decaying fungi, plant pathogen fungi, and human pathogenic fungi as well. These actions have been reported to its ability to disrupt the cell walls of both fungi and bacteria [9].

 

ANTINEOPLASTIC

In modern days, cancer therapy is constantly evolving, and with plenty of anticancer agents coming from plant sources, it is important to continue research on new plants to find new and better medicines. A study done investigating the effects of a methanol extract of Turnera diffusa out of Mexico found that “Turnera diffusa has a cytotoxic effect on MDA-MB-231 breast cancer cells, and that this activity, at least in part, owes itself to the activity of apigenin” [2, pg. 303].

Other suggestions for damiana's effects against cancer involve eugenols suggested action of interfering with the uptake of aromatic and branched-chain amino acids into cells. It is a common idea that starvation of cancer cells of phenylalanine and its subsequent tyrosine may be used as an anticancer strategy [5].

 

ANXIOLYTIC

Damiana has long been used with CNS disorders. Researchers out of India were able to extract and isolate the known anxiolytic compound apigenin from Turnera aphrodisiaca. These researchers suggested this constituent be the bioactive marker towards ensuring effectiveness with this botanical [6].

Damiana can also be smoked to achieve a tranquilizing and slightly euphoric sensation. Many use this herb in this way to manage low levels of stress/anxiety, or acute stress from a long day. 

 

APHRODISIAC

Damiana has been shown to produce a significant improvement in the sexual function of impotent rats in a study done in Italy. This study did, however, show no improvement in the sexual activity of sexually potent rats. The study concluded that “[damiana] might act mainly by increasing central noradrenergic and dopaminergic tone, and possibly (indirectly) oxytocinergic transmission” [1].

Other mechanisms include induced relaxation of the corpus cavernosum [11], and the suggested action that the volatile oil may irritate the urethral mucous membranes [10]. 

 

Toxicity

Damiana has been found to be non-toxic to animals and humans [8].

Traditional use of this plant has been suggested for abortive purposes, and therefore, should never be used during pregnancy until its safety in this case can be proven. 

 

Cautions:

Due to the hypoglycemic action of this herb, it may interfere with antidiabetic medications, and therefore, caution is advised if also taking medications for diabetes to lower blood sugar.


Synergy:

Eugenol has been found to be synergistic with antibiotics due to its effect on disrupting the cell walls of bacteria (especially gram-negative bacteria), and the efflux pumps located there [4].

Shows indications of being synergistic with other GABA inhibitors, or other anxiolytics such as passionflower or muira puama. 


Author:

Justin Cooke

The Sunlight Experiment

Updated: June 2017


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References:

  1. Arletti, R., Benelli, A., Cavazzuti, E., Scarpetta, G., & Bertolini, A. (1999). Stimulating property of Turnera diffusa and Pfaffia paniculata extracts on the sexual behavior of male rats.Psychopharmacology, 143(1), 15-19. doi:10.1007/s002130050913
  2. Avelino-Flores, M. D., Cruz-López, M. D., Jiménez-Montejo, F. E., & Reyes-Leyva, J. (2015). Cytotoxic Activity of the Methanolic Extract of Turnera diffusa Willd on Breast Cancer Cells. Journal of Medicinal Food, 18(3), 299-305. doi:10.1089/jmf.2013.0055
  3. Balunas, M., & Kinghorn, A. (2010). Natural Compounds with Aromatase Inhibitory Activity: An Update. Planta Med, 76(11), 1087-1093. doi:10.1055/s-0030-1250169
  4. Coutinho, H. D., Costa, J. G., Lima, E. O., Falcão-Silva, V. S., & Siqueira, J. P. (2009). Herbal therapy associated with antibiotic therapy: potentiation of the antibiotic activity against methicillin – resistant Staphylococcus aureus by Turnera ulmifolia L. BMC Complementary and Alternative Medicine, 9(1), 13. doi:10.1186/1472-6882-9-13
  5. Darvishi, E., Omidi, M., Bushehri, A. A., Golshani, A., & Smith, M. L. (2013). The Antifungal Eugenol Perturbs Dual Aromatic and Branched-Chain Amino Acid Permeases in the Cytoplasmic Membrane of Yeast. PLoS ONE, 8(10), e76028. doi:10.1371/journal.pone.0076028
  6. Kumar, S., Madaan, R., & Sharma, A. (2008). Estimation of apigenin, an anxiolytic constituent, in Turnera aphrodisiaca. Indian Journal of Pharmaceutical Sciences, 70(6), 847. doi:10.4103/0250-474x.49143
  7. Lee, S. H., Moon, J. Y., Jung, S. J., Kang, J. G., Choi, S. P., & Jang, J. H. (2015). Eugenol Inhibits the GABAA Current in Trigeminal Ganglion Neurons. PLOS ONE, 10(1), e0117316. doi:10.1371/journal.pone.0117316
  8. Taylor, L. (2005). The healing power of rainforest herbs: A guide to understanding and using herbal medicinals. Garden City Park, NY: Square One Publishers.
  9. Wang C, Zhang J, Chen H, Fan Y, Shi Z. (2010). Antifungal activity of eugenol against Botrytis cinerea. Tropical Plant Pathology. 35. 3. http://dx.doi.org/10.1590/S1982-56762010000300001
  10. Bone, K. (2003). A clinical guide to blending liquid herbs: Herbal formulations for the individual patient. Edinburgh [u.a.: Churchill Livingstone.
  11. Arletti, R., Benelli, A., Cavazzuti, E., Scarpetta, G., & Bertolini, A. (1999). Stimulating property of Turnera diffusa and Pfaffia paniculata extracts on the sexual behavior of male rats. Psychopharmacology, 143(1), 15-19.

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