Depression:

  • More common in women than men
  • Theories to the causes of depression
    • Biogenic amine hypothesis
      • This states that depression is caused by a deficiency of monoamines, particularly noradrenaline and serotonin. 
    • Upregulation and downregulation of receptors is another theory
    • There are other theories as well. 
      • Second messenger systems
         

Aetiology:

Depression is very common, yet remains fairly misunderstood. Although treatments for depression are available, both naturopathically and through pharmaceutical therapies, the biochemical mechanisms responsible are inconsistent and difficult to confirm. 

there are several theories as to what is causing depression, the most prevalent and well accepted of which is the biogenic amine hypothesis. This theory states that depression is caused by a defficiency of the monoamine neurotransmitters, which includes dopamine, serotonin, epinephrine, and norepinephrine. The focus has been on serotonin and norepinephrine (also called noradrenaline). 

Other theories involve upregulated and downregulated states of neurotransmitter receptors rather than the neurotransmitters themselves. Second messenger systems are also suspect, and makes up the most complex and hardest to test and understand of the theories. 


Special Considerations:

  1. Much more prevalent in women then men. 
  2. High cortisol will eventually lead to a reduction in serotonin, giveing a mechanism for long term stress in depression based on the biogenic amine hypothesis model. 

Therapeutic Aims:

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Botanical Medicine For Depression:


Nutritional Considerations:


Depression Formula:


Author:

Justin Cooke

The Sunlight Experiment

Updated: May 2017


Recent Blog Posts:

References:

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