NSAID Summary:

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COX Pathways:

Cyclooxygenase (COX) catalyzes the conversion of arachidonic acid to prostaglandin and thromboxane precursors. There are 2 COX inh9ibitors (COX-1 and COX-2), with some indication of a third (COX-3). 


Pharmacology:

NSAIDS are...


Adverse Reactions:

  • ...

Tolerance: 

...


How Pain Works:

Pain is... 


  • drug name
  • Generic name
  • Trade name
  • Chemical name
  • Main action or classification (ex: adenosine antagonist)
  • Receptor
  • Source: synthetic, naturally ocurring, or herbal derrivative
  • Where did the original mocecule come from?
  • Common dosage
  • Chemical structure

NSAID Drug List:

 

TEMPLATE

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Generic Name: INSERT
Brand Name(s): INSERT
Main Action: INSERT
Receptor: INSERT
CYP450 Enzyme Metabolism INSERT
Source: INSERT
Common Dosage: xxx

Aspirin

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Generic Name: Aspirin
Brand Name(s): Durlaza, Ecotrin, Ecpirin, Fasprin, Halfprin, Miniprin
Main Action: Irreversible inhibition of COX-1 and COX-2
Classification: Salicylate
CYP450 Enzyme Metabolism 2C9
Source: Salicylic acid is a naturally ocurring phenolic acid. Acetylsalicylic acid is a synthetic derrrivative.
Common Dosage: Low Dose: 100 mg/day
Regular dose: 300-600 mg every 4-6 hours

Celecoxib

After numerous accounts of COX inhibitor medications causing ulcers due to inhibition of protective COX-1 metabolites, Celebrex was produced as a COX-2 specific inhibitor. The side effects were reduced, but myocardial infarcts increased significantly instead.

Long list of serious side effects. See Drugs.com.

Generic Name: Celecoxib
Brand Name: Celebrex
Main Action: COX-2 specific inhibitor (No COX-1 activity)
Classification: Coxib
Source: Synthetic
Common Dosage: 100-400 mg once or twice daily

Diclofenac

Diclofenac is an anti-inflammatory drug used for migraine headaches and other inflammatory pain. This is not a common NSAID, but can be used if allergies present to other NSAID's. Long list of serious side effects. See Drugs.com

Generic Name: Diclofenac
Brand Name: Diclofenac sodium, Fenac, Voltaren, Cataflam, Clonac, Diclohexal and more.
Main Action: Inhibits prostaglandin synthesis. Possibly through COX pathways.
Classification: Acetic acid
Source: Synthetic
Common Dosage: 25-50 mg 3 times a day (oral)
Topical, eyedrop, and suppository doses also available.

Diflusinal

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Generic Name: INSERT
Brand Name(s): INSERT
Main Action: INSERT
Classification: Saicylate
CYP450 Enzyme Metabolism INSERT
Source: INSERT
Common Dosage: xxx

Ibuprofen

Ibuprofen is one of the most commonly used NSAID medications. It is more appropriate for children over 6 months than Aspirin to reduce pain, inflammation, and fever.

Long list of mild and serious side effects. See Drugs.com

Generic Name: Ibuprofen
Brand Name: Advil, Genpril, Midol IB, Proprinal, Brufen, Bugesic, Nurofen, ProVen, ACT-3, Panafen, Rafen, and more.
Main Action: Inhibition of prostaglandin synthesis. Possibly through COX pathways.
Classification: Proprionic acid
Source: Synthetic
Common Dosage: Maximum of 1200 mg/day divided into 3-4 doses.

Indomethacin

Indomethacin is mainly used to reduce the pain caused by osteoarthritis, rheumatoid arthritis, gouty arthritis, and ankylosing spondylitis.

Generic Name: Indomethacin
Brand Name: Indocin, Tivorbex
Main Action: Inhibition of prostaglandins.
Classification: Acetic acid
Source: Synthetic
Common Dosage: 50 mg 3 times/day

Mefenamic acid

Mefenamic acid is used as a short term (7 days or less) analgesic for mild-moderate pain. This medication is not safe for use in children under the age of 14. Long list of serious side effects associated with this medication. See Drugs.com

Generic Name: Mefenimic acid
Brand Name: Ponstel
Main Action: Inhibition of prostaglandins.
Classification: Fenemate
Source: Synthetic
Common Dosage: 500 mg once, then 250 mg every 6 hours. DO NOT exceed 1 weeks use.

Meloxicam

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Generic Name: Meloxicam
Brand Name: Mobic, Vivlodex
Main Action: INSERT
Classification: Oxicam
Source: INSERT
Common Dosage: 7.5-15 mg orally once/day

Naproxen

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Generic Name: Naproxen
Brand Name: Aleve, EC-Naprosyn, Flanax Pain Reliever, Midol Extended Relief, Naprelan 375, Naprosyn, Anaprox, and more.
Main Action: INSERT
Classification: Propionic acid
Source: INSERT
Common Dosage: 750-500 mg twice/day

Piroxicam

Some quick example text to build on the card title and make up the bulk of the card's content.

Generic Name: Piroxicam
Brand Name: Feldene
Main Action: INSERT
Classification: Oxicam
Source: INSERT
Common Dosage: 20 mg orally once/day

Sulfasalazine

Sulfazine is mainly used to treat moderate to severe ulcerative colitis, and rheumatoid arthritis in children and adults who have not had relief from other NSAID medications.

Generic Name: Sulfasalazine
Brand Name(s): Azulfidine, Sulfazine
Main Action: INSERT
Classification: Salicylate
CYP450 Enzyme Metabolism INSERT
Source: INSERT
Common Dosage: 3-4 g/day divided into 2-4 doses