Psilocybin is an entheogenic alkaloid contained in several fungal species throughout the world. The mechanism of action for this alkaloid mainly involves modulation of the 5-HT (serotonin) receptors, causing visual and auditory disturbances, and abstract thought patterns.

There's evidence of extensive traditional use involving this substance, mainly surrounding the ancient central and South American regions of the world. The hallucinations brought on by the mushroom species that contains it was thought to make a connection with the spirit world.

More modern applications of this alkaloid involve the 5-HT modulating ability, such as for nootropic or antidepressant benefit.


New to nootropics? Check out this Introduction to Nootropics!

Where Does Psilocybin Come From?

The main source for this alkaloid is Psilocybe spp. (magic mushrooms). there are various species of mushrooms that contain the alkaloid.

Psilocybe cubensis mushrooms

Psilocybe cubensis mushrooms


Herbal Actions:

  • Antidepressant
  • Psycedelic
  • Anxiolytic
  • Serotonergic

+ Indications

  • Depression
  • Anxiety

+ Contraindications

  • Doses higher than 0.5g may cause hallucinations

+ Mechanisms

  • Serotinergic
  • 5-HTP modulator


Less than 300 mg/day (microdose)

  • • Higher doses are therapeutic in single doses only!
  • • 2-3 g is psycedelic.
  • It is not wise to exceed 5 g at any given time except under the supervision of an expert of entheogenic medicine. (yes they exist).


The Sunlight Experiment does not condone any illegal activity, comsume at your own risk and follow your local laws.


Chemical Description:

Still compiling research. 



Still compiling research. 



Psilocybin has not been found to possess toxic side-effects. Some experience mild gastrointestinal discomfort as a result of the chitin contained in the fungus bodies.

Still compiling research.


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Further Reading

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The Psilocybin Solution

By Simon G Powell

View Book
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Food Of The Gods

By Terence McKenna

View Book
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The Doors Of Perception

By Aldous Huxley

View Book


Justin Cooke, BHSc

The Sunlight Experiment

Updated: March 2017

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