What is Chinese Skullcap?
Chinese skullcap is very similar to the popular nervine herb, American skullcap (Scutellaria lateriflora), however, there are some major differences in their use.
Chinese skullcap is far better for treating immune conditions, including the allergic response, inflammation, and infections. American skullcap, on the other hand, is much better for conditions involving the neurological system.
What Is Chinese Skullcap Used For?
Chinese skullcap is mainly used for inflammatory, or allergic conditions. It is useful for nasal congestion, upper respiratory tract infections, seasonal allergies and hay fever, arthritis, and migraine headaches.
Traditional Uses of Skullcap
+ Traditional Chinese Medicine
Pinyin
Huáng Qín
Taste
Bitter [18, 19]
Energy
Cold [18, 19]
Channels
Lung, Gallbladder, Stomach large intestine [19]
Actions
Dispels (clears) heat, expels (drains) damp heat, drains fire, detoxificant, stops bleeding, calms the fetus [1, 18, 19].
Indications
The roots are generally the preferred part of the plant in Chinese medicine, used for fevers, cough with thick sputum, pneumonia, nausea, vomiting, hemoptysis, jaundice, viral hepatitis, diarrhoea, dysentry-like diseases, painful urination, hypertension, restless foetus, carbuncles, allergic conditions, hyperlipidemia, vexing heat,internal accumulation of heat toxin, bleeding due to heat exuberance, internal accumulation of damp-heat, and dermoatitis [1, 17, 18].
Cautions
Do not use with cold syndromes of deficiency type [19].
In traditional Chinese medicine, skullcap is considered one of the 50 fundamental herbs, and as such is one of the most commonly used herbs in this medical system [2].
+ Tibet
In Tibet, S. barbata is the most common species, where it is juiced (both root and leaves) and used for wounds, fevers, indigestion, and gastric disturbances [2].
+ Western Herbal Medicine
In North America, the main species used traditionally was S. lateriflora. The native Americans here used the leaves to treat sore eyes, chills, fever, colds, coughs, heart problems, and as a laxative. The roots were used as an emmenagogue, and abortifacient, antidiarrheal, nervine, treat kidney disorders, cold and flu, and to prevent smallpox [2].
The leaves were often used in the form of a tea, or steamed and eaten as a vegetable [2].
Priest and priest suggested skullcap fas a diffusive, and a stimulating and relaxing vasodilator and trophorestorative. They suggested it useful for treating nervous irritation of the cerebro-spinal nervous system, nervous exhaustion, post-febrile nervous weakness, chorea, hysteria, agitation, epileptiform convulsions, insomnia, and restless sleep. [4].
In western botanical practice, skullcaps of all varieties are used mainly as a nervine, but also for conditions such as chorea, convulsions, hysteria, nervous tension, intermittent fever, neuralgia, insomnia, and restlessness. [2, 17].
Herb Details: Chinese Skullcap
Herbal Actions:
- Antiviral (root)
- Anti-inflammatory
- Antiallergic
- Antibacterial
- Nervine
- Antispasmodic
- Hypotensive
- Anxyiolytic
- Astringent (Mild)
- Antitumor
Part Used
Whole plant
Family Name
Lamiaceae
Distribution
Native to China, Russia, Mongolia, Japan, Korea, and Siberia.
Constituents of Interest
- Baicalein
- Scutellarin
- Catalpol
- Melatonin
Common Names
- Chinese Skullcap
- Baical Skullcap
- Mad Dog Skullcap
- Toque (French)
- Huang Qin (Chinese)
- Helmet Flower
- Hoodwort
Botanical Information
Chinese skullcap is a member of the Lamiaceae family (mint family). This family is large, containing as much as 236 genera and 7500 species. This family is characterized by square stems, and aromatic nature.
Habitat Ecology, & Distribution
Skullcap generally grows in moist, sandy areas, but can be found in all sorts of environments the world over. It has even been found growing up to about 6000 feet in altitude [2].
It is native to China, Mongolia, Japan, Korea, Siberia, Russia [2].
Pharmacology & Medical Research
+ Antiallergic
The flavonol and flavone content of skullcap (especially baicalein and wogonin) were shown to inhibit histamine release from the mast cells [1, 20]. It was found to moderate mast cell release of histamine by restoring IL-8 and TNF-alpha expression, as well as inhibiting MAP kinase expression [21].
Luteolin and baicalein were shown to inhibit IgE mediated allergic reactions in mice [22].
+ Cancer
Chinese skullcap (Scutellaria baicalensis) flavonoids such as oroxylin A has been the subject of a great deal of study. It has been found to possess inhibitory actions against such inflammatory factors as NF-kB [13] and was found to induce apoptosis in cancer cell lines via inducing translocation of p53 to mitochondria [14].
+ Inflammation
Scutellaria baicalensis flavonoids (especially oroxylin A) has been found to have anti-inflammatory (and subsequent anti-cancer) actions [11, 12]. It has been found to possess inhibitory actions against such inflammatory cytokines as TNF-alpha, and IL-6 [10]. Wogonin and baicalein were both found to be direct COX-2 inhibitors [20].
+ Anxiolytic
Flavonoids from Scutellaria baicalensis were suggested to produce anxiolytic actions via the GABA receptors [4]. More research is needed.
+ Antiviral
Scutellaria baicalensis (Chinese skullcap) is the preferred antiviral species by herbalist Stephen Buhner. He reports the roots are a broad antiviral. The mechanism of action is through hemagglutinin and neuraminidase inhibition — effectively putting a halt to viral replication. Additionally, the extract may prevent viral fusion with cells, offer cytoprotective against viral-initiates cytokines, reduces the expression of the viral matrix protein gene, inhibiting viral release from infected cells, inhibiting viral cytokine cascades, and increases apoptosis of virus infected cells, and finally via direct virucidal actions [2 (Pg. 133)].
Some of these actions can be due to the flavonoids mosloflavone, oroxylin A, and norwogonin, contained within Scutellaria baicalensis. All of these flavonoids purified from skullcap were found to inhibit Coxsackievirus B3 induced cell death. Oroxylin A especially has proven to possess positive effects against viral infection. This chemical was found in particular to reduce viral titers in the pancreas, and decrease inflammatory cytokine levels including IL-6, and TNF-alpha [10] which are both well known to contribute significantly to the cytokine storm associated with the damage viral infection causes [2].
Scutellaria baicalensis was also shown to have broad-spectrum antiviral actions in other studies against viruses such as influenza virus through an inhibitory effect against neuraminidase enzyme activity in the virus [15]. It has also been shown effective against respiratory syncytial virus (RSV) [16],
Scutellaria baicalensis extracts have been found effective against:
- Various influenza viruses [2,15, 23]
- Human Immunodeficiency Virus (HIV-1) [2,24]
- Respiratory Syncytial Virus (RSV) [2,16]
- Epstein Barr Virus [20]
- Hepatitis B Virus (HBV) [20]
+ Hepatic
Liver fibrosis is characterized by excessive deposition of extracellular matrix in the liver parenchyma. It is associated with the inflammatory and reparative phase of hepatic fibrosis, conducted by activated hepatic stellate cells. [5, 6]. The flavonoids contained in Scutellaria baicalensis was suggested to inhibit TGF-β fibrosis pathway in a Chinese herbal combination (San Huang Shel Shin Tang) which contains Rheum officinale, Scutellaria baicalensis, and Coptis chinensis, all of which contain similar flavonoid components such as baicalein [6].
Skullcap (Scutellaria baicalensis) alone has been found in past studies to provide a protective action against acute liver toxicity [7-9].
Phytochemistry
Scutellaria baicalensis reportedly contains more than 295 different compounds:
+ Volatile oils
- Limonene
- Terpineol
- d-Cadinene
- Caryophyllene
- trans-beta-farnesene
- beta-humulene
+ Flavonoids
- Baicalein
- Baicalin
- Scutellarein
- Wogonin
- Oroxylin-A-7-O-glucoronide
- Moslofavone
- Norwogonin
- Apigenin
- Hispidulin
- Luteolin
- Scutellarin (bitter glycoside)
+ Irridoids
- Catalpol
+ Others
- Melatonin
- Serotonin
- Naringenin
- Tannin
- Fat
- Sugar
- Cellulose
Clinical Applications Of Chinese Skullcap:
Chinese skullcap is reliable as a way to reduce the allergic response in allergic conditions, as well as inflammation. The root is a promising treatment option for a range of different viral infections, including influenza and HIV.
Synergy
Herbalist Stephen Buhner suggests skullcap as a synergist herbal for its potentiating effects on other herbs.
He considers this herb especially synergistic with the pharmaceutical antivirals and antibacterials ribavirin, albendazole, ciprofloxacin, and amphotericin B. He reports that skullcap is synergistic with antibiotics by its ability to inhibit the Nor A efflux pump of resistant bacteria [2].
He also reports that skullcap can dose-dependently inhibit (the effects increase as dose increases) the CYP3A4 enzymes in the liver which are responsible for drug metabolism [2]. This allows the drugs to persist longer and may potentiate the effectiveness of these drugs.
Suggested to be synergistic as an antiviral with licorice [2].
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References:
Bone, K. (2003). A clinical guide to blending liquid herbs: Herbal formulations for the individual patient. Edinburgh [u.a.: Churchill Livingstone. (Pg. 83-85)
Buhner, S. H. (2013). Herbal antivirals: Natural remedies for emerging resistant and epidemic viral infections. MA: Storey Publishing. (Pg. 125-143).
A Modern Herbal. (1931). Skullcaps. Retrieved from http://www.botanical.com/botanical/mgmh/s/scullc34.html
Hoffmann, D. (2003). Medical herbalism: The science and practice of herbal medicine. Rochester, VT: Healing Arts Press. (Pg. 582)
Parsons CJ, Takashima M, Rippe RA. (2007). Molecular mechanisms of hepatic fibrogenesis. J Gastroenterol Hepatol. 22:S79–84.
Yeh, Y., Ting, W., Kuo, W., Hsu, H., Lin, Y., Shen, C., Huang, C. (2016). San Huang Shel Shin Tang beta-cyclodextrin complex augmented the hepatoprotective effects against carbon tetrachloride-induced acute hepatotoxicity in rats. BMC Complementary and Alternative Medicine, 16(1). doi:10.1186/s12906-016-1127-8
Chien CF, Wu YT, Tsai TH. (2011). Biological analysis of herbal medicines used for the treatment of liver diseases. Biomed Chromatogr. 25:21–38.
Nan JX, Park EJ, Kim YC, Ko G, Sohn DH. (2002). Scutellaria baicalensis inhibits liver fibrosis induced by bile duct ligation or carbon tetrachloride in rats. J Pharm Pharmacol. 54:555–63.
Ye X, Feng Y, Tong Y, Ng KM, Tsao S, Lau GK, Sze C, Zhang Y, Tang J, Shen J, Kobayashi S. (2009). Hepatoprotective effects of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced acute liver hepatotoxicity in rats. J Ethnopharmacol. 124:130–6.
Kwon, B., Song, J., Song, H., Kang, J. W., Hwang, S. N., Rhee, K., Ko, H. (2016). Antiviral Activity of Oroxylin A against Coxsackievirus B3 Alleviates Virus-Induced Acute Pancreatic Damage in Mice. PLOS ONE, 11(5), e0155784. doi:10.1371/journal.pone.0155784
Li HN, Nie FF, Liu W, Dai QS, Lu N, Qi Q, et al. (2009). Apoptosis induction of oroxylin A in human cervical cancer HeLa cell line in vitro and in vivo. Toxicology. 2009; 257(1–2):80–5. Epub 2009/01/13. doi: 10.1016/j.tox.2008.12.011 PMID: 19135124.
Kumagai T, Muller CI, Desmond JC, Imai Y, Heber D, Koeffler HP. (2007). Scutellaria baicalensis, a herbal medicine: anti-proliferative and apoptotic activity against acute lymphocytic leukemia, lymphoma and myeloma cell lines. Leuk Res. 31(4):523–30. Epub 2006/09/30. doi: 10.1016/j.leukres.2006.08.019 PMID: 17007926.
Wang X, Sun Y, Zhao Y, Ding Y, Zhang X, Kong L, et al. (2016). Oroxyloside prevents dextran sulfate sodium induced experimental colitis in mice by inhibiting NF-kappaB pathway through PPARgamma activation. Biochemical pharmacology. 106:70-81. Epub 2016/03/08. doi: 10.1016/j.bcp.2016.02.019 PMID: 26947454.
Qiao C, Lu N, Zhou Y, Ni T, Dai Y, Li Z, et al. (2016). Oroxylin a modulates mitochondrial function and apoptosis in human colon cancer cells by inducing mitochondrial translocation of wild-type p53. Oncotarget. Epub 2016/03/10. doi: 10.18632/oncotarget.7927 PMID: 26958937.
Hour MJ, Huang SH, Chang CY, Lin YK, Wang CY, Chang YS, et al. (2013). Baicalein, Ethyl Acetate, and Chloroform Extracts of Scutellaria baicalensis Inhibit the Neuraminidase Activity of Pandemic 2009 H1N1 and Seasonal Influenza A Viruses. Evid Based Complement Alternat Med. 2013:750803. Epub 2013/07/19. doi: 10.1155/2013/750803 PMID: 23864896; PubMed Central PMCID: PMC3705751.
Ma SC, Du J, But PP, Deng XL, Zhang YW, Ooi VE, et al. (2002). Antiviral Chinese medicinal herbs against respiratory syncytial virus. J Ethnopharmacol. 79(2):205–11. Epub 2002/01/22. PMID: 11801383.
Barnes, J., Anderson, L. A., & Phillipson, J. D. (2007). Herbal medicines (3rd ed.). London, United Kingdom: Pharmaceutical Press.
Yang, J., Huang, H., Zhu, Li-Jiang, & Chen, Y. (2013). Introduction to chinese materia medica (3rd ed.). (Pg 96-98).
Wu, J. N. (2005). An illustrated Chinese materia medica. New York: Oxford University Press.(Pg. 582-583).
Braun, L., & Cohen, M. (2010). Herbs & natural supplements: An evidence-based guide Vol. 2. Sydney: Elsevier Australia. (Pg. 49-50).
Jung, H., Kim, M. H., Gwak, N., Im, Y., Lee, K., Sohn, Y., Yang, W. M. (2012). Antiallergic effects of Scutellaria baicalensis on inflammation in vivo and in vitro.Journal of Ethnopharmacology, 141(1), 345-349. doi:10.1016/j.jep.2012.02.044
LIM, B. O. (2004). Efficacy of Wogonin in the Production of Immunoglobulins and Cytokines by Mesenteric Lymph Node Lymphocytes in Mouse Colitis Induced with Dextran Sulfate Sodium. Bioscience, Biotechnology, and Biochemistry, 68(12), 2505-2511. doi:10.1271/bbb.68.2505
Hour, M., Huang, S., Chang, C., Lin, Y., Wang, C., Chang, Y., & Lin, C. (2013). Baicalein, Ethyl Acetate, and Chloroform Extracts ofScutellaria baicalensisInhibit the Neuraminidase Activity of Pandemic 2009 H1N1 and Seasonal Influenza A Viruses.Evidence-Based Complementary and Alternative Medicine, 2013, 1-11. doi:10.1155/2013/750803
Li, B. Q., Fu, T., Dongyan, Y., Mikovits, J. A., Ruscetti, F. W., & Wang, J. M. (2000). Flavonoid Baicalin Inhibits HIV-1 Infection at the Level of Viral Entry. Biochemical and Biophysical Research Communications, 276(2), 534-538. doi:10.1006/bbrc.2000.3485
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