Alpha-GPC Summary:

Alpha-GPC is one of the most popular choline donors in the nootropic market. This is because of its effectiveness, high potency, and high level of safety.

Many of the premier nootropic formulas on the market make use of this molecule for its ability to provide the brain with the choline necessary to produce the neurotransmitter acetylcholine. This neurotransmitter plays a key role in memory development, as well as numerous other cognitive processes.

When combined with a cholinergic such as racetams, the effectiveness of both substances can be significantly enhanced. In fact, whenever taking racetams, it is always recomended to consume alpha-GPC or an alternative choline donor in order to avoid side effects of choline depletion and to optimise the effectiveness fo the nootropic.


Where Does It Come From?

Alpha-GPC is produced in small amounts in the human body, and can be found in plant sources such as soy. It has also been found in milk. 

soybeans are a source of alpha-gpc

General Actions:

  • Cognitive stimulant (Mild)
  • Memory enhancer
  • Neuroprotective
  • Increases focus

Specific Actions:

  • Choline donor
  • Nutrient used in the formation of cell membranes

Indications:

  • In combination with cholinergic nootropics
  • To improve memory and concentration
  • Protect agains neurodegenerative disorders

Dosage

60 - 1400 mg/day

Dosage range is heavily debated.

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Chemical Description:

Alpha-GPC is the short name for L-alpha-glycerylphosphorylcholine. [1]. 

It is a  a water-soluble, deacylated phosphatidylcholine derivative [2]. 


Extractions/Synthesis:

Still compiling research. 



Pharmacology And Medical Research:

Alzheimer's Disease

In a multicenter, double blind, placebo controlled trial consisting of 261 individuals, the choline precurser choline alphoscerate (alpha-GPC) was shown to produce a significant improvement in Alzheimer's symptoms over 180 days of treatment. The scores were based on numerous cognitive assessment scales such as ADAS-Cog, MMSE, GDS, ADAS-Behav, ADAS-Total, CGI, and GIS. The dosage used in this trial was 1200 mg/day broken into 3 doses of 400 mg. [2].

Choline preloading is slowly becomming a popular treatment option for the condition of Alzheimer's disease as a result of studies like this. Phosphatidylserine is also popular choline source for this application.



Growth Hormone

1000 mg of Alpha-GPC was shown to significantly increase levels of growth hormone in male patients 60 minutes after ingestion. The mechanism of action was reported to be through the action of acetylcholine-stimulated catecholamine [3].


Neuroprotective

In an experimental study, alpha-GPC was shown to have a neuroprotective effect on irradiated hippocampus of mice. More research is required to comfirm these effects in humans. [1]. 

 

Toxicity

Alpha-GPC is considered safe by the FDA and remains unregulated.

Some users have reported sleep disturbances after taking alpha-GPC due to some mild cognitive stimulating actions. Avoid taking alpha-GPC too close to the desired sleeping time in order to avoid this. 

 

Synergy:

Alpha-GPC is suggested to be synergistic with cholinergic nootropics including the racetam family of nootropics. 

Alpha-GPC and other choline donors are also considered to be synergistic with antiacetylcholinesterase nootropics for a similar effect. 

 


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Author:

Justin Cooke

The Sunlight Experiment

Updated March 2017


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References:

  1. Plangár, I. (2014). Radio-neuroprotective effect of l-alpha-glycerylphosphorylcholine (GPC) in an experimental rat model. Journal of Neuro-Oncology, 119(2), 253-261. doi:10.1007/s11060-014-1489-z
  2. Toke´s T, Varga G, Garab D, Nagy Z, Fekete G, Tuboly E, Planga´r I, Ma´n I, Szabo´ RE, Szabo´ Z, Volford G, Ghyczy M, Kaszaki J, Boros M, Hideghe´ty K (2014) Peripheral inflammatory activation after hippocampus irradiation in the rat. Int J Radiat Biol 90:1–6
  3.