Noopept is a synthetic nootropic substance with effects very similar to piracetam. Noopept is much more potent however, and requires a dosage about a hundred times smaller (10-40 mg compared to 4800 mg for piracetam).
It was created in 1996, and is now one of the most popular nootropic substances on the market. Its incredible potency, high level of safety, and effectiveness on concentration and memory make it a perfect addition to nootropic formulas.
Where Does it Come From?
Synthetic nootropic molecule created in 1996.
The name noopept is the brand name for the molecule. The patent owners are in Russia.
It is also known as GVS-111.
- Mild cognitive stimulant
- NMDA receptor modulator
- Cholinosensitising (speculative) 
- To improve memory
- Increase creativity
- Promote workflow efficiency
- Protective in the event of cognitive trauma, or oxidative damage
Noopept is the brand name for N-phenylacetyl-L-prolylglycine ethyl ester. It is commonly grouped together in the racetam family, but lacks the 2-oxo-pyrollidine skeleton that defines racetams.
Noopept is based off the endogenous neuropeptide cycloprolylglycine . It's a dipeptide conjugate of Piracetam.
Still compiling research.
Noopept crosses the gastrointestinal tract with a Tmax of 0.116 hours which is equivelent to 7 minutes. It reaches a Cmax of 0.82 mcg/mL in blood serum in rats. The dose used to determine this was 50 mg/kg, but was reported to be nearly identical to a 5 mg/kg dosage. Measurements taken both in the brain and in systemic blood circulation were nearly identical, suggesting that noopept can easily cross the blood brain barrier. .
The half life of noopept in rats was found to be approximatly 16 minutes in rats, and undetectable after 25 minutes. This doesn't consider cycloprolylglycine, which is believed to be an active metabolite. . Changes in brain wave function is noted to last over 70 minutes, indicating the matabolites having a strong active role in the compound. .
The major metabolite of Noopept is the endogenous neuropeptide Cycloprolylglycine (Proline and Glycine in a cyclic configuration). .
Single doses and long term dosing have both been shown to increase NGF, and BDNF mRNA concentrations in the hippocampus (of rats). In the long term study, there appeared to be no development of tolerance, and a greater increase of NGF levels. .
Noopept is suggested to have a cholinosensitising effect in vitro .
Noopept was shown to produce anxiolytic activity in rats ,
Noopept has been found to produce antidepressant activities in rat models [8, 9].
The toxicity of noopept is incredibly low. In pre-clinical studies on toxicity, researchers reported "no allergenic, immunotoxic, and mutagen activity" despite 6 months of heavy dosing (100 mg/kg). This dosage range had no effect on the progeny of the affected mice. . Putting this dose in perspective, a normal dosage of noopept is between 10-40 mg .day for the average adult (~60 kg). Thats less than 1% of the tested dosage.
Possible synergy with cholinergics.
The Sunlight Experiment
Updated March 2017
Recent Blog Posts:
- Kovalenko, L. P., Smol'nikova, N. M., Alekseeva, S. V., Nemova, E. P., Sorokina, A. V., Miramedova, M. G., ... & Daugel, D. N. (2001). Preclinical study of noopept toxicity. Eksperimental'naia i klinicheskaia farmakologiia, 65(1), 62-64.
- Gudasheva TA, et al Anxiolytic activity of endogenous nootropic dipeptide cycloprolylglycine in elevated plus-maze test . Bull Exp Biol Med. (2001)
- Boiko SS, et al Pharmacokinetics of new nootropic acylprolyldipeptide and its penetration across the blood-brain barrier after oral administration . Bull Exp Biol Med. (2000)
- Vorobyov V, et al Effects of nootropics on the EEG in conscious rats and their modification by glutamatergic inhibitors . Brain Res Bull. (2011)
- Gudasheva TA, et al The major metabolite of dipeptide piracetam analogue GVS-111 in rat brain and its similarity to endogenous neuropeptide cyclo-L-prolylglycine . Eur J Drug Metab Pharmacokinet. (1997)
- Ostrovskaya RU, et al Noopept stimulates the expression of NGF and BDNF in rat hippocampus . Bull Exp Biol Med. (2008)
- Neznamov GG, Teleshova ES Comparative studies of Noopept and piracetam in the treatment of patients with mild cognitive disorders in organic brain diseases of vascular and traumatic origin . Neurosci Behav Physiol. (2009)
- Uyanaev AA, Fisenko VP, Khitrov NK Effect of noopept and afobazole on the development of neurosis of learned helplessness in rats . Bull Exp Biol Med. (2003)
- Uyanaev AA, Fisenko VP Studies of long-term noopept and afobazol treatment in rats with learned helplessness neurosis . Bull Exp Biol Med. (2006)
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