Caffeine Summary:

Caffeine is perhaps the most popular stimulant in the world. It's contained within 3 of the most popular beverages the world has ever seen; coffee, tea, and yerba maté. 

Caffeine is an alkaloid that works mainly by competitively inhibiting adenosine on our neurons. Adenosine acts normally to slow the firing of our nerves, resulting in sleepiness. When caffeine inhibits these from taking action, it effectively inhibits our sleepiness. 

Although not technically a nootropic, caffeine is a useful addition to nootropic formulas for its ability to give us faster reflexes, stimulate the CNS, and keep us awake when we would normally be feeling tired. 

New to nootropics? Check out this Introduction to Nootropics!

Where Does It Come From?

Multiple species of plants contain caffeine, including Coffea spp., Camellia spp., Kola nitidia, Puallinia cupana, Ilex spp. 

Caffeine can also be synthesized quite easily in a lab. 

Camellia sinensis

The Tea Plant

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Coffea officinalis

Coffee seeds

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Ilex paraguariensis

Yerba maté

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Paullinea cupana


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coffee beans caffeine source

General Actions:

  • CNS Stimulant
  • Inhibits sleepiness
  • Increases blood pressure
  • Improves Productivity
  • Cardiotonic
  • Diuretic

Specific Actions:

  • Adenosine antagonist
  • Vasoconstrictor
  • Diuretic
  • Relaxes smooth muscle
  • Stimulates cardiac muscle
  • Modulates internal calcium
  • Inhibits cyclic nucleotide phosphodiesterases


200 -300 mg Per day

(3-4 cups of coffee/day spread out through the day)


  • Add to nootropic formulas
  • Extending work efficiency
  • Headaches (not all types)


200 - 300 mg/day

Equivalent to 3-4 cups of coffee split up throughout the day.
Best taken with L-Theanine and/or Theobromine.

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Chemical Description:

Caffeine is a colorless, odorless, white chrystaline powder.

Very low water solubility.


One method of extraction is to boil coffee beans in water with lime or magnesium oxide to precipitate tannins and coloring matter. Charcoal may be used to remove other coloring agents, and the caffeine will rechrystalize out of the hot water easily. [1]. 

Another method is to use supercritical carbon dioxide or obtain byproduct of decaffeinated coffee or teas. [1]. 

Pharmacology/Medical Research:


Adenosine Receptor Antagonism

Still compiling research. 


Despite previous reports online, there is no evidence for caffeine being a carcinogen.


Synergy with related alkaloid theobromine, and amino acid L-theanine. 

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  1. Pub Chem. (n.d.). caffeine | C8H10N4O2 - PubChem. Retrieved February 17, 2017, from