Cholesterols Role In Heart Disease

Cholesterol

Cholesterol isn't famous for its role in our cell membranes, or as a precurser to many of our hormones of our body. Rather, it's famous for its role in heart disease. Cholesterol is blamed almost exclusively for the millions of deaths each year due to heart disease. 

In light of this, medications used to reduce heart disease, most commonly called the statin drugs, earn billions of dollars each year as people attempt to reduce their chances of developing or worsening high cholesterol levels.

Cholesterols role in heart disease

What is cholesterol?

Cholesterol is a type of fat created by your liver. It's used in the body for a magnitude of important processes.  

  • It's used to give our cells strength and rigidity
  • it's a building block for hormones like testosterone and estrogen
  • It makes up the bile that breaks your food down after you eat
  • It helps form the synapses in your brain that are necessary for your brain to think and store memories
  • It's turned into vitamin D that regulates calcium levels throughout your body.

All of these things are absolutely necessary for life to exist. Cholesterol is not a “bad guy”, it is an important building block for the body. 

Why then is cholesterol blamed for being the number one killer in America, Australia, and the second leading killer in Canada? Let’s explore this idea a bit further, but first let's discuss how cholesterol enters our bloodstream in the first place.   

How Cholesterol Travels

Cholesterol is a fat. That means it won't dissolve into water. Have you ever seen what happens when vegetable oil is placed into a glass of water? All the oil separates and floats to the top. The denser, heavier substance (water) sinks to the bottom, while the lighter substance (oil) floats to the top. The same thing would happen if we combined the oily cholesterol with our watery blood. The fat (including cholesterol) would try to separate from the water, and would end up accumulating on the outside of our blood vessels. 

In order to travel safely and effectively through our blood, it needs to bind to a special carrier protein. This protein changes the structure of cholesterol enough to make it soluble in the watery blood. These carrier proteins are referred to as lipoproteins. Lipo means fats or lipids, and protein refers to its classification as a protein. When you stick the two together, you get a lipoprotein, or “fat-protein”.  

There are a few different types of lipoproteins in the body, but the mains ones to consider in terms of heart disease are LDL, and HDL. 

LDL stands for low density lipoprotein. it works to transport cholesterol from the liver where it is prodiuced, to the other cells of the body. Due to the direction of travel, LDL is considered the "bad guy" because high levels of this lioprotein in the blood means cholesterol is begining to build up in the body. 

HDL stands for high density lipprotein and is used for the exact oopposite. this protien acts to remove cholesterol from the bodys cells, and return it to the liver to break it down and turn it into bile salts for digestion. When this protein is high, it means the body is reducing its cholesterol levels. this is the so called "good cholesterol". 

Cholesterol-buildup-diagram.jpg

 

Measuring Cholesterol

Cholesterol itself is never found in circulation alone. It will always be held on one of these proteins. To test for it then, doctors actually look for these lipoproteins in the blood. LDL and HDL levels are measured and compared. High cholesterol is defined as having 240 mg/dL and higher total cholesterol levels in the bloodstream. 

Concern begins around 200 mg/dL total cholesterol levels. 

LDL itself is considered high at 160 mg/dL and very high above 190 mg/dL. 

 

How Cholesterol Leads to Heart Disease

The problem herein lies in the tendency for some individuals to have more cholesterol going out from the liver, than back to the liver. If more cholesterol is going out than is coming back in, it is clear that cholesterol is building up somewhere in the body, and this cholesterol cycle is no longer balanced or healthy. These buildups tend to be in the arteries since they have direct contact with circulating cholesterol. 

The way this system works is very complex, and we don’t have a definitive answer as to the exact reasons why cholesterol will build up on the blood vessel walls. There are several theories to this, some better than others, which we will get into with more detail later on. 

There is an undeniable correlation with LDL cholesterol and the existence of cardiovascular disease. This makes sense when you think about what the role LDL has. Its job is to deliver cholesterol from the  liver to the cells of the body. If you have a high LDL count in the blood compared to HDL (which removes the cholesterol), your body is building up more cholesterol than it's removing. The chances that this cholesterol is accumulating is therefore far greater.

If your HDL levels adequately match the amount of LDL, there isnt a problem because cholesterol is being delivered to the cells , but is getting removed efficiently and therefore is not likely to build up and cause a blockage of an artery. As mentioned before cholesterol is actually a very useful molecule. If we were to block LDL completely in an attempt to stop heart disease, we would actually have a long list of other issues. We wouldn't be able to produce testosterone or estrogen, cells wouldn't be able to divide and grow, and we would likely suffer deadly consequences from the lack of Vitamin D (which is produced from the cholesterol molecule).

Another Way To Look At It

The way cholesterol can cause the heart to fail is fairly abstract and complex. Here is a metaphor to make the concept a little clearer.