Graviola (Annona muricata)

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Graviola Overview:

Graviola is a large tropical tree with a rich history of traditional use for conditions like cancer, parasitic infection, insomnia, and dysentery. Modern use remains very similar, mainly focusing on tension headaches and muscle aches, insomnia, diabetes, cancer, hypertension, and parasitic infection.

Although the entire plant has been used as medicine by various traditional medical systems, the most common form the plant is available in today is as a leaf extract, and raw leaves intended for tea.

Graviola is gaining in popularity outside worldwide as a general health supplement, blood sugar regulator, and anticancer agent. As a result it is getting easier to find the herb as time goes on. It is likely this tea will become a staple in Western herbal medicine in the coming years.

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+ Indications

  • Adjunctive Cancer Treatment (Various)
  • Bacterial infection
  • Cold/Flu
  • Diabetes
  • Dysentery
  • Fever
  • Jaundice
  • Pain
  • Parasitic infection

+ Contraindications

  • May exacerbate Parkinson's Disease symptoms (Acetogenin content)
  • Caution advised in combination with other hypoglycemic drugs due to potential additive effect.

Main Herbal Actions:

  • Anticancer
  • Antinflammatory
  • Antioxidant
  • Antispasmodic
  • Anticonvulsant
  • Antidepressant
  • Antidiabetic
  • Antibacterial
  • Antiarthritic
  • Antilithic
  • Antimalarial
  • Bradycardic
  • Digestive stimulant
  • Febrifuge
  • Hepatoprotective
  • Hypotensive
  • Sedative
  • Vasodilator
 

Main Uses:

Graviola is mainly used as an adjunctive treatment for cancer, especially leukemia and other haematological cancers, as well as prostate, colon, and breast cancers.

Graviola is also popular as an antidiabetic herb, and can be used to reduce hypertension, especially in combination with diabetes or metabolic syndrome.

Graviola is a potent antiparasitic, useful for a wide range of different parasitic species, including worms, protozoa, and bacterial parasites.

 

Weekly Dose

Part Used

  • Leaves

Family Name

  • Annonaceae

Distribution

  • North & South America, The Caribbean, Indonesia, Western Africa, Pacific Islands

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Constituents of Interest

  • Acetogenins
  • Alkaloids (reticulin, coreximine, coclarine and anomurine)
  • Essential oils (β-caryophyllene, δ-cadinene, epi-α-cadinol and α-cadinol)
  • Quercetin

Common Names

  • Graviola
  • Custard Apple Tree
  • Soursop
  • Annona
  • Guanabana (South America)

Quality

  • Cool*

Pregnancy

  • Unknown

Taste

  • Sour

Duration of Use

  • Avoid long term use.
 

Botanical Info:

Graviola is a large tree, growing to a height of 10m. It requires high humidity, warm weather, and high annual rainfall in order to thrive. It produces large, edible fruits with an acidic taste (hence the common name soursop).

There are over 130 different genera in the Annonaceae family, and around 2300 different species. The Annona genus itself has about 70 different species. Annona muricata is the most commonly grown worldwide.

 

Research Overview:

Still compiling research

Level Of Research:

 

Clinical Applications Of Graviola:

Graviola is useful for parasitic infection, including protozoan, and helminth parasites. It's used as a mild sedative and antispasmodic, and can be very useful for gastrointestinal inflammation and dysbiotic conditions.

Graviola is also a popular treatment for diabetes by slowing lipid peroxidation, and restoring islet beta-cells in the pancreas.

It's commonly used as an adjunctive treatment of cancer, especially haematological cancers and colon cancer.

 

Cautions:

Graviola has been reported to increase symptoms of Parkinson's Disease.

Caution advised in combination with other hypoglycemic drugs due to potential additive effect.

 
 

Monograph Coming Soon

 

Recent Blog Posts:

References:

  1. Moghadamtousi, S. Z., Fadaeinasab, M., Nikzad, S., Mohan, G., Ali, H. M., & Kadir, H. A. (2015). Annona muricata (Annonaceae): a review of its traditional uses, isolated acetogenins and biological activities. International journal of molecular sciences, 16(7), 15625-15658.
  2. De Sousa, O. V., Vieira, G. D. V., De Pinho, J. D. J. R., Yamamoto, C. H., & Alves, M. S. (2010). Antinociceptive and anti-inflammatory activities of the ethanol extract of Annona muricata L. leaves in animal models. International journal of molecular sciences, 11(5), 2067-2078.
  3. Torres, M. P., Rachagani, S., Purohit, V., Pandey, P., Joshi, S., Moore, E. D., ... & Batra, S. K. (2012). Graviola: a novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism. Cancer letters, 323(1), 29-40.
  4. Coria-Tellez, A. V., Montalvo-Gónzalez, E., Yahia, E. M., & Obledo-Vázquez, E. N. (2016). Annona muricata: A comprehensive review on its traditional medicinal uses, phytochemicals, pharmacological activities, mechanisms of action and toxicity. Arabian Journal of Chemistry.
  5. Gavamukulya, Y., Abou-Elella, F., Wamunyokoli, F., & AEl-Shemy, H. (2014). Phytochemical screening, anti-oxidant activity and in vitro anticancer potential of ethanolic and water leaves extracts of Annona muricata (Graviola). Asian Pacific journal of tropical medicine, 7, S355-S363.
  6. Arroyo, J., Martínez, J., Ronceros, G., Palomino, R., Villarreal, A., Bonilla, P., ... & Quino, M. (2009, September). Efecto hipoglicemiante coadyuvante del extracto etanólico de hojas de Annona muricata L (guanábana), en pacientes con diabetes tipo 2 bajo tratamiento de glibenclamida. In Anales de la Facultad de Medicina (Vol. 70, No. 3, pp. 163-167). UNMSM. Facultad de Medicina.
  7. Adewole, S., & Ojewole, J. (2009). Protective effects of Annona muricata Linn.(Annonaceae) leaf aqueous extract on serum lipid profiles and oxidative stress in hepatocytes of streptozotocin-treated diabetic rats. African journal of traditional, complementary and alternative medicines, 6(1).
  8. Adeyemi, D. O., Komolafe, O. A., Adewole, O. S., Obuotor, E. M., Abiodun, A. A., & Adenowo, T. K. (2010). Histomorphological and morphometric studies of the pancreatic islet cells of diabetic rats treated with extracts of Annona muricata. Folia morphologica, 69(2), 92-100.
  9. Adewole, S. O., & Caxton-Martins, E. A. (2006). Morphological changes and hypoglycemic effects of Annona muricata linn.(annonaceae) leaf aqueous extract on pancreatic β-cells of streptozotocin-treated diabetic rats. African Journal of Biomedical Research, 9(3).