anticholesterol

Pine (Pinus spp.)

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About the Pine Tree

The mighty pine tree is one of the most common trees on earth — making up close to 1% of the plant population of earth. They can be found thriving in both the coldest, and hottest environments on the planet.

All parts of the pine tree are used medicinally, and the wood is an importance source of lumbar for construction.

The leaves (needles) are an excellent source of vitamin A and C, the resin is a powerful antibacterial and carminative agent, the bark and pine nuts are highly nutritive, and the pollen is used as an analgesic, male tonic, and longevity-enhancement agent.

The pine tree is, and always has been an invaluable ally to humans.

 

Featured Pine Pollen Products

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Pine Pollen Powder

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Pine Pollen Tincture

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Pine Pollen Capsules

 
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What Are Pine Trees Used For?

There are so many uses for the pine tree, it’s hard to list them all. The bark, needles, seeds, and pollen are incredibly nutritious, and the resin contains powerful antimicrobial and vulnerary compounds.

Humans have been using the pine tree as food and medicine for thousands of years in almost every Northern culture on earth. Many of the traditional medical uses for pine trees still stand today — but have become less popular over other more exotic herbs.

A common theme with herbal medicine is that it’s usually the least interesting, most common plant species that have the most to offer. Yet we’re always looking for that new exotic herb or supplement to use instead.

The most popular use of the pine tree today is in the form of topical salves made from the resin and male tonic supplements made from the pine pollen. Pine nuts are also a common source of nutrition you can pick up at any grocery store.

The needles and bark are also exceptionally nutritious and can be made into a tea or decoction (respectively) to support general health, as well as treating debility, fatigue, and nutritional deficiencies.

+ Pine Needle Uses

Pine needles make for an excellent tea. They're rich in vitamin A, Vitamin C, and a host of medicinal essential oils.

Pine needle tea is great for supporting the immune system, releasing phlegm from the lungs, easing a sore throat, curbing gas and bloating, or warming up on a cold winter hike.

An infusion of the needles can also be applied topically to the skin as an antimicrobial and vulnerary.

Fresh needles collected in the spring can be eaten raw and add a pleasant "piney" or "rosemary" flavor to the dish. You can also infuse these fresh pine sprigs with honey or butter.

A tincture can be made from the needles using a high alcohol menstrum (at least 95%). Use, sparingly.

+ Pine Resin Uses

Pine resin seeps out of cuts and scratches of the tree — it's used to seal the wounds and prevent infection. As a result, it's no surprise this pine resin has exceptional antimicrobial properties. It's insecticidal, anti-fungal, and antibacterial.

The resin makes for an excellent addition to topical salves designed to speed wound healing.

You can also make or buy tinctures of pine resin using a high-proof alcohol as the solvent. These are useful for releasing phlegm from the lungs and eliminating gas and bloating from the digestive tract. However, use it sparingly as the resin can be irritating to the GI tract in high amounts.

+ Pine Pollen Uses

Pine pollen has a long history of use in Asia for promoting strength and male virulity. High-proof extracts of the pollen are used by older men to maintain testosterone levels. There's a lot of promise for this effect in the scientific literature (more on this later) — but it's important to note that pine pollen is not an anabolic steroid and can't be used to boost testosterone in younger men. It only appears to work if testosterone levels are low to begin with.

Outside male virility, pine pollen is an excellent nutritional supplement for men and women alike. It's rich in the amino acids, minerals, and vitamins required for optimal health.

+ Pine Bark Uses

Pine bark is rich in vitamin C and A and a few unique medicinal components. The bark can be decocted to make a strong bitter tea with a host of medicinal benefits. Some herbalists use the bark for heart disease, varicose veins, clotting disorders, and cancer.

+ Pine Nut Uses

Pine nuts, like the rest of the pine tree, are very nutritious. They're rich in vitamins B1, B2, B6, E, C, D2, D3, and A.

Pine nuts are also rich in nicotinamide, folic acid, B-carotin, potassium, sodium, calcium, magnesium, phosphorus, iron, manganese, copper, zinc, and selenium — to name a few.

 

Traditional Uses of Pine Trees

Anybody living in proximity to these common forest plants (especially in Northern climates) have developed a set of uses for the herb — many of which are the same all over the world.

The pine tree has been used for coughs, allergies, urinary tract infections, sinus infections, skin infections, debility, joint pain, inflammatory diseases, immune deficiencies, scurvy, and much more.

Native American tribes used the pine tree as an important source of nutrition during the winter months — consuming the nuts, bark, and needles of the pine tree.

Early explorers to reach North America from Europe eventually started using pine needle tea to ward off scurvy.

There are countless uses for this impressive tree as well when you consider its nutritive benefits. Almost any medical condition can stand to benefit from optimal nutrition, which explains why the tree has been used in traditional medicines for almost any cause of debility.

The resin was also considered a valuable ingredient in topical salves for skin conditions, infections, and insect bites.

The boughs of the pine tree were used as an insect-repellant bedding to eliminate common pests like bedbugs or fleas.

Herb Details: Pine Trees

Herbal Actions:

  • Analgesic
  • Anti-Inflammatory
  • Anticholesterolaemic
  • Astringent
  • Carminative
  • Male Tonic
  • Nutritive
  • Respiratory Tonic

Relevant Species:

  • Pinus edulis
  • Pinus ponderosa
  • Pinus aristata
  • Pinus strobus
  • Pinus contorta
  • Pinus strobus
  • Pinus sylvestris

Dosages

Part Used

Needles, inner-bark, pollen, seeds, resin

Family Name

Pinaceae

Distribution

Temperate forests around the world

Constituents of Interest

  • a-terpenol
  • Linalool
  • Caryophyllene
  • Eugenol

Common Names

  • Pine
  • Scot's Pine
  • Scotch Pine
  • Logepole Pine
  • Jack Pine

CYP450

  • Unknown

Pregnancy

  • Topical applications of pine resin, as well as pine needle tea is safe to use during pregnancy — however, avoid pine pollen or pine resin tinctures while pregnant.

Duration of Use

  • Long-term use of all parts of this plant is acceptable

Botanical Information

The Pinus genus consist of roughly 144 different species of coniferous trees. It’s one of the oldest plants on earth — dating back at least 200 million years.

Pine trees are incredibly common, they’re found on every continent, and dominate forests in the Norther hemisphere. One report suggests the humble pine tree makes up about 1% of the entire plant population of earth.

No matter where you go in the northern Hemisphere, you’re likely to find pine trees a permanent member of the landscape. However, if you look more closely, different regions are home to a specific species of pine tree.

 

Harvesting & Preparation

All parts of the pine tree can be used medicinally. The leaves make a nutritious tea, the bark can be decocted into a strong tea, the resin can be made into antimicrobial salves, and the pollen can be supplemented as a male tonic.

Different parts of the tree should be harvested in different seasons:

  1. Pine Pollen — the pine tree only releases its pollen in the early spring or summer. Each tree releases an ton of it. Collect it by placing bags over the catkins and giving it a shake.

  2. Pine Needles — these can be harvested anytime, but spring is the best in order to get the young growth. Newer growth has a much better taste and higher terpene concentrations.

  3. Pine pitch (resin) — This part can be harvested all year. I like to harvest it in the winter when it’s extra hard as I find this easier to collect in chunks rather than making a sticky mess of evertthing when the resin is still gooey.

  4. Pine Bark — You can collect this part of the tree anytime of the year. I find it best in the spring, summer.

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Pharmacology & Medical Research

+ Antinociceptive (Pain-Reduction)

In animal studies, an ethanol extract of pine pollen (100 and 200 mg/kg orally) produced significant inhibition of both pain transmission and inflammation compared to the control group [1]. (Species tested (Pinus densiflora).

+ Anticholesterolaemic

The needles of pine trees (Pinus morrisonicola) has been shown to inhibit copper-induced low-denisty lipoproteins (LDL) oxidation [2]. The study involved four different solvent extracts, but the ethyl acetate extract showed the greatest antioxidant activity overall.

+ Anti-Inflammatory

Several studies have shown different parts of the pine tree to have anti-inflammatory effects on various inflammatory enzymes and messenger molecules.

The needles were shown to possess COX-2 inhibitory activities in animal models [2].

+ Longevity

One of the longest-running applications of the pine pollen — dating back thousands of years in China — was for promoting long-life. This was especially true in men, where the pollen was used to delay the effects of aging, and sustain male virility long into old age. In traditional Chinese medicine, pine pollen is considered a jing tonic. Jing is a term used to describe “life essence” — it’s essentially our virility. When jing runs out, we die. Chinese medicine considers pine pollen a tonic for the lungs, kidneys, heart, spleen, and liver — all five major organs in the Chinese medical system.

The modern term for this effect is an adaptogen — something that improves our ability to resist both internal and external stresses and maintain homeostasis (balance).

In order to offer such broad benefits to the body, pine pollen must act on a central regulatory system. Some herbs, such as ginseng do this by acting on the hypothalamus — which is the region in the brain that manages homeostasis within the body. Other herbs, like cannabis achieve this by boosting the effects of a regulatory system called the endocannabinoid system.

A study published in 2012 looked at the potential anti-aging effects of pine pollen [3]. The study injected mice with D-galactose — which is a compound used to induce premature aging by increasing the formation of advanced glycation end-products (AGEs). Pine pollen extract was found to hinder the production of AGE at doses between 500 and 1500 mg/kg. This effect was noted to be comparable in effects to 100mg/kg aminoguanidine — a well-known longevity-enhancement medication through AGE pathways.

+ Testosterone

There was a study published in 2013 that showed black pine tree pollen (Pinus nigra) contained epi-testosterone, as well as a handful of other androgenic compounds (5α-androstane-3α,17β-diol, 5β-androstane-3α,17β-diol and etiocholanolone) [1]. The problem is that the testosterone levels contained in pine pollen were so insignificant it was unrealistic to expect any change in testosterone levels for those taking the supplement. It’s estimated that 10 grams of pine pollen contains about 0.8 micrograms of testosterone [4].

To put this in perspective, the usual dose of injectable testosterone is over 100 mg. This is an injectable form of testosterone too — which has 100% absorption rate. Oral ingestion of testosterone has significantly less absorption — closer to 3 –7%.

While you can’t use pine pollen as a natural source of testosterone, it does offer improvements to testosterone levels in older men through alternate mechanisms.

The improvement in male health and libido after using pine pollen is most likely a combination of its potent nutritional profile and anti-inflammatory benefits. Pine pollen is particularly rich in amino acids like nicotinic acid and pantothenic acid — both of which have been shown to play a major role in the function of the testes where testosterone is produced.

The benefits of pine pollen on testosterone levels are most notable in older men experiencing the natural drop-off of testosterone levels. There’s no evidence to suggest pine pollen can boost testosterone levels in healthy, younger men.

 

Phytochemistry

The entire pine tree is a rich source of nutrition. The bark, leaves, and pollen are all high in vitamins and minerals, while the resin is particularly rich in terpenes and other volatile compounds.

+ Pine Pollen Constituents:

Amino acids, riboflavin, nicotinic acid, pantothenic acid, pyridoxine, biotin, inositol, folic acid, vitamin D2, vitamin D3. Some species (Scot’s pine — Pinus sylvestrus) has been found to contain testosterone, epitestosterone, and androstenedione — however, the concentrations are too low to reasonably offer any direct benefits through supplementation. The male tonic effects of pine pollen are primarily the result of other compounds, rather than from the androgens themselves.

+ Pine Resin Constituents

Abietic acid, dehydroabietic acid, elliotic acid, isopimaric acid, levopimaric acid, palustric acid, pimaric acid, sandaracopimaric acid, strobinic acid, volatile oils.

+ Pine Needle Constituents

Leucocyanidin, neoabietinic acid, pinosylvin monomethyl ester, strobic acid, antioxidants, volatile oils including α-terpineol (30.2%), linalool (24.47%), limonene (17.01%), anethole (14.57%), caryophyllene (3.14%), and eugenol (2.14%).

+ Pine Bark Constituents

Abietic acid, cis-abienol, leucocyanidin, neoabietinic acid, pinosylvin, monomethyl ester, strobic acid, volatile oils.

 

Cautions & Safety Information:

All pine species are considered safe. There is one species of tree that resembles the pine tree — the yew tree — which is toxic. The yew tree can be differentiated by the smaller, flat needles and little red berries.

The pollen of the pine tree is a common cause for allergy — take with caution when using pine pollen for the first time to ensure there are no allergic reactions.

Be careful when using tinctures of the pine resin to avoid causing gastrointestinal irritation. Start with a very low dose before increasing gradually once you get a feel for how it affects you directly.

 

Author:

Justin Cooke, BHSc

The Sunlight Experiment

(Updated March 2020)

 

Recent Blog Posts:

 

Popular Herbal Monographs

 

References:

[1] — Choi, E. M. (2007). Antinociceptive and antiinflammatory activities of pine (Pinus densiflora) pollen extract. Phytotherapy Research, 21(5), 471-475.

[2] — Yen, G. C., Duh, P. D., Huang, D. W., Hsu, C. L., & Fu, T. Y. C. (2008). Protective effect of pine (Pinus morrisonicola Hay.) needle on LDL oxidation and its anti-inflammatory action by modulation of iNOS and COX-2 expression in LPS-stimulated RAW 264.7 macrophages. Food and chemical toxicology, 46(1), 175-185.

[3] — Mao, G. X., Zheng, L. D., Cao, Y. B., Chen, Z. M., Lv, Y. D., Wang, Y. Z., ... & Yan, J (2012). Antiaging effect of pine pollen in human diploid fibroblasts and in a mouse model induced by D-galactose. Oxidative medicine and cellular longevity, 2012.

[4] — Chamawan, P., Thisayakorn, K., & Phornchirasilp, S. (2017). Effects of Pine Pollen Extract in Relieving Hot Flushes in Sex Hormone-Deficienct Rats. Thai Journal of Pharmacology, 39(1), 19-37.

Black Horehound (Ballota nigra)

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What is Black Horehound?

Black horehound is best known for its offensive odour — which resembles stale sweat.

Despite the unfortunate smell of this mint-relative, it has a lot to offer therapeutically.

Black horehound is one of the oldest medicinal herb species from Europe. It has a long history of use for infectious diseases including rabies and parasites, as well as for nausea and vomiting caused by neurological disorders.

This herb is a bit of a jack of all trades — but master of none. It offer reliable nervine, antispasmodic, antimicrobial, and anticholesterolaemic effects — all thanks to five unique phenylpropanoid glycosides contained in the leaves, stems, and roots of the herb.

 

What is Black Horehound Used For?

Many of the tradition uses of the herb have yet to be validated. The primary traditional uses for the herb that still stand today are for treating motion sickness or other causes of nausea or vomiting of neurological origin.

This herb is also still used as an antimicrobial for the digestive tract and topically on the skin.

Newer applications for the herb are aimed towards high cholesterol levels and diabetes.

 

Traditional Uses of Black Horehound

Black horehound was used for a lot of different applications. It was also a common remedy for motion sickness or any vomiting caused by neurological origins (rather than digestive).

Topically, the leaves were used to treat wounds, burns, and infection. Some herbalists even gave the herb as an enema for parasitic worms.

In Europe, where the herb originated from, the flowering tops were used to treat rabies after getting bitten by a rabid dog.

 

Herb Details: Black Horehound

Herbal Actions:

  • Antibacterial
  • Anticholesterolaemic
  • Antiemetic
  • Antifungal
  • Antioxidant
  • Antiprotozoal
  • Antispasmodic
  • Expectorant
  • Hypoglycaemic
  • Nervine
  • Sedative

Weekly Dose

Part Used

Flowering Tops

Family Name

Lamiaceae

Distribution

Europe & North America

Constituents of Interest

  • Verbascoside
  • Forsythoside B
  • Arenarioside
  • Ballotetroside
  • Malic Acid

Common Names

  • Black Horehound
  • Black Stinking Horehound
  • Fetid Horehound
  • Stinking Roger

CYP450

  • Unknown

Pregnancy

  • Avoid black horehound if pregnant or breastfeeding

Duration of Use

  • insert

Botanical Information

Black horehound originated from Europe but is now widespread across North America as well. The herb can grow over 1 meter tall and tends to grow on the side of the road in rural areas.

What this plant is best known for is its disagreeable odor — which can be described as stale sweat. The Greek name, ballo translates to “getting rid of”, or “throwing away”. This smell protects the herb by repelling both animals and humans.

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Pharmacology & Medical Research

+ Anticholesterolaemic

One of the major causes of atherosclerosis is the result of oxidization of low-density lipoproteins LDL) [1].

Some of the phenolic compounds in black horehound (verbascoside, forsythoside B, arenarioside, and ballotetroside) were found to inhibit LDL oxidation through Cu2+ pathway [2].

+ Antimicrobial

Five phenolic compounds from black horehound were investigated to explore their antimicrobial potential. Of these five, three (verbascoside, forsythoside B, arenarioside) were found to have moderate activity against Proteus mirabilis, Salmonella typhi, and Staphylococcus aureus [3, 4].

Another study looked at the antimicrobial effects of each part of the plant (leaves, roots, and stems). The results suggested the crude extract of the roots had the best inhibitory activity on the strains tested (Enterococcus faecalis, Escherichia coli, Klensiella pneumonia, Proteus miribalis, Salmonella typhi, and Staphylococcus aureus, Aspergillus fumigates, Aspergillus niger, Fusarium solani, and Leishmania) [5]. The leaf and stem chloroform extracts had similar antimicrobial action.

+ Sedative

Phenylpropanoid compounds from black horehound were found to bind to benzodiazepine, dopaminergic, and morphinic receptors in animals [6, 4]. This provides a mechanism of action for the traditional sedative uses of the herb — but more research is needed to further elucidate these findings.

 

Phytochemistry

The flowering tops (the part used medicinally) are rich in diterpenoid lactones (labdane type) — such as ballotenol, ballotinone, 7alpha-acetoxymarrubiin, hispanolone, and preleosibirin.

The tops are also rich in phenolic compounds (luteolin-7-lactate, luteolin-7-glucosyl-lactate), phenylpropanoid glycosides (verbascoside, forsythoside B, arenarioside, ballotetroside), organic acids (quinic acid), and volatile oils.

 

Cautions & Safety Information:

Black horehound is considered a safe herb, with little chances of experiencing any side effects.

Allergies to the herb have been noted, so caution is advised if using the herb for the first time. Always start with a small amount first to see how you react before using a full dose.

Black horehound may interact with the following medication classes:

  • Antipsychotic medications (overlap in receptor activation)

  • Anti-Parkinson’s disease medications (overlap in dopaminergic action)

  • Sedatives (overlap in sedative effects and benzodiazepine receptor activation)

  • Iron supplements (black horehound has been suggested to prevent the absorption of iron)

 

Author:

Justin Cooke, BHSc

The Sunlight Experiment

(Updated March 2020)

 

Recent Blog Posts:

Featured Herb Monographs

 

References:

[1] — Steinberg, D. (1997). Low density lipoprotein oxidation and its pathobiological significance.

[2] — Seidel, V., Verholle, M., Malard, Y., Tillequin, F., Fruchart, J. C., Duriez, P., ... & Teissier, E. (2000). Phenylpropanoids from Ballota nigra L. inhibit in vitro LDL peroxidation.

[3] — Didry, N., Seidel, V., Dubreuil, L., Tillequin, F., & Bailleul, F. (1999). Isolation and antibacterial activity of phenylpropanoid derivatives from Ballota nigra.

[4] — Al-Snafi, A. E. (2015). The Pharmacological Importance of Ballota nigra–A review.

[5] — Ullah, N., Ahmad, I., & Ayaz, S. (2014). In vitro antimicrobial and antiprotozoal activities, phytochemical screening and heavy metals toxicity of different parts of Ballota nigra.

[6] — Daels-Rakotoarison, D. A., Seidel, V., Gressier, B., Brunet, C., Tillequin, F., Bailleul, F., ... & Cazin, J. C. (2000). Neurosedative and antioxidant activities of phenylpropanoids from Ballota nigra.

Walnut (Juglans nigra)

Walnut is a very versatile tree. The bark is used as a potent astringent, and the green, unripe husks make for a great antiparasitic agent. The husks can be extracted and made into...